Triple-negative breast cancer (TNBC) has long been considered one of the most difficult types to combat. A therapy called Dato-DXd nearly doubled the time patients lived without their breast cancer growing.
It is aggressive, often strikes women under the age of 40 and often resists standard treatments. A recent global clinical trial has shown promising results in extending survival for patients with TNBC, a study reveals.
According to the report, published by SingHealth, on April 3, 2026, all of the patients had either untreated, locally recurrent and inoperable cancer or metastatic TNBC for whom immunotherapy was not an option.
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Dato-DXd belongs to a class of drugs called antibody-drug conjugates (ADCs). Think of them as biological homing missiles.
The incidence of TNBC is estimated at 10%-20%. It does not respond to hormonal therapy treatment; therefore, the available choices were few.
Even when patients are eligible to undergo immunotherapy, 70% are not. They must therefore undergo regular chemotherapy treatment, which has been largely unsuccessful.
In the 644-patient trial, however, patients taking Dato-DXd had their tumours shrink by 63%, whereas those receiving chemotherapy experienced a tumour reduction of 29%. Additionally, patients had an average survival time of 23.7 months.
According to an expert at the National Cancer Institute, the data show that we now have the much-needed novel tool to help women affected by this devastating disease. The drug is being fast-tracked for review by the U.S. Food and Drug Administration (FDA) and other global health agencies.
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Disclaimer:
This content is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting or changing any medication or treatment.